2. Signaling Pathways
  3. GPCR/G Protein
    Neuronal Signaling
  4. Neuropeptide Y Receptor

Neuropeptide Y Receptor

NPY receptor

Neuropeptide Y Receptor

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Neuropeptide Y receptors belong G protein-coupled receptor superfamily and comprise various subtypes. There are currently five cloned NPY receptor subtypes in mammals, termed Y1, Y2, Y4, Y5, and Y6. Neuropeptide Y receptors mediate a variety of physiological responses including feeding and vasoconstriction.

Subtypes Y1, Y2, Y4 and Y5 are expressed in humans. They are present mainly in the central and peripheral nervous systems as well as other tissues, such as the cardiovascular system. Their physiologic ligands are the neurotransmitter Neuropeptide Y and the 2 hormones peptide YY (PYY) and pancreatic polypeptide (PP).

Neuropeptide Y and its receptors regulate important biological and pathophysiological functions, such as blood pressure, neuroendocrine secretions, seizures, neuronal excitability and neuroplasticity.

Neuropeptide Y Receptor Isoform Specific Products:

Neuropeptide Y Receptor Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-132240
    SF-22
    		Antagonist 99.49%
    SF-22 is a potent and brain-penetrant antagonist of neuropeptide Y receptor (Y2R), with the IC50 value of 750 nM. SF-22 plays an important role in neurological disease.
    SF-22
  • HY-P3877A
    (Leu31,Pro34)-Peptide YY (human) TFA
    		Agonist 98.63%
    (Leu31,Pro34)-Peptide YY (human) (TFA) is the TFA form of (Leu31,Pro34)-Peptide YY (human) (HY-P3877). (Leu31,Pro34)-Peptide YY (human) (TFA) is a Peptide YY (HY-P1514) derivative and is a potent and selective Y1 agonist with a KD of 1.0 nM.
    (Leu31,Pro34)-Peptide YY (human) TFA
  • HY-165125
    (S)-VU0637120
    		Antagonist 99.5%
    (S)-VU0637120 is a Y4R antagonist that effectively reduces the binding response of its endogenous ligand, pancreatic polypeptide (PP), on Y4R, with an IC50 value of 2.7 μM. (S)-VU0637120 binds to the allosteric site of Y4R, which is located in the core region of the Y4R transmembrane structure, near the binding pocket of pancreatic polypeptide (PP), with a KB value of 300-400 nM. (S)-VU0637120 holds potential for research in the field of metabolic diseases.
    (S)-VU0637120
  • HY-123671
    CYM2503
    		Modulator
    CYM2503 is a putative GalR2-positive allosteric modulator. CYM2503 increases the latency to first electrographic seizure and decreases the total time in seizure. CYM2503 also attenuates electroshock-induced seizures in mice. Galanin receptors type 1 (GalR1) and/or type 2 (GalR2) represent unique pharmacological targets for the research of seizures and epilepsy.
    CYM2503
  • HY-107726A
    BIBP3226
    		Antagonist 98.78%
    BIBP3226 is a potent and selective neuropeptide Y Y1 (NPY Y1) and neuropeptide FF (NPFF) receptor antagonist, with Kis of 1.1, 79, and 108 nM for rNPY Y1, hNPFF2, and rNPFF, respectively. BIBP3226 displays anxiogenic-like effect.
    BIBP3226
  • HY-107732
    JNJ-5207787
    		Antagonist 98.00%
    JNJ-5207787 is a nonpeptidic, selective and penetrate the blood-brain barrier neuropeptide Y Y2 receptor (Y2) antagonist. JNJ-5207787 inhibits the binding of peptide YY (PYY) with pIC50s of 7.0 and 7.1 for human Y2 receptor and rat Y2 receptor, respectively. JNJ-5207787 is >100-fold selective versus human Y1, Y4, and Y5 receptors.
    JNJ-5207787
  • HY-P11291A
    NNC0165-1273 TFA
    NNC0165-1273 (TFA) is the trifluoroacetic acid of NNC0165-1273 (HY-P11291). NNC0165-1273 is an analog of gut hormone peptide YY (PYY3-36). NNC0165-1273 has a superior affinity for Y2 receptor over Y1, Y4, and Y5 receptor. NNC0165-1273 has a potent anorectic effect and significantly reduces nighttime and ghrelin-induced food intake by producing early satiety. NNC0165-1273 inhibits ghrelin-induced cFos expression in NPY/AgRP neurons. NNC0165-1273 can be used for antiobesity therapies research.
    NNC0165-1273 TFA
  • HY-P1131A
    M617 TFA
    		99.38%
    M617 TFA is a selective galanin receptor 1 (GAL1) agonist, with Kis of 0.23 and 5.71 nM for GAL1 and GAL2, respectively. M617 TFA, acting through its central GAL1, can promote GLUT4 expression and enhance GLUT4 content in the cardiac muscle of type 2 diabetic rats.
    M617 TFA
  • HY-P1025
    M40
    		Modulator
    M40 is an antagonist or a weak agonist for galanin receptor depending on different subtypes of galanin receptors in the brain, hypothalamus, hippocampus, amygdala and pancreas.
    M40
  • HY-107728
    S 25585
    		Antagonist 99.13%
    S 25585 is a potent and selective neuropeptide Y (NPY) Y5 receptor antagonist. S 25585 reduces food intake but not through blockade of the NPY Y5 receptor.
    S 25585
  • HY-P10148
    N-Acetyl [Leu28, Leu31] neuropeptide Y (24–36)
    		Agonist 98.03%
    N-Acetyl [Leu28, Leu31] neuropeptide Y (24–36) is a selective agonist of neuropeptide Y Y2 receptor. N-Acetyl [Leu28, Leu31] neuropeptide Y (24–36) attenuates cardiac vagal action in anaesthetised rats.
    N-Acetyl [Leu28, Leu31] neuropeptide Y (24–36)
  • HY-101986A
    BIIE-0246 hydrochloride
    		Antagonist 99.0%
    BIIE-0246 hydrochloride (AR-H 053591 hydrochloride) is a potent and selective NPY2R (neuropeptide Y receptor 2) antagonist with an IC50 value of 15 nM for rat [125I]PYY3-36. BIIE-0246 hydrochloride decreases the expression of p-AKT S473, P-p44/42 MAPK under the NPY-stimulated. BIIE-0246 hydrochloride reduces albuminuria in ADR nephropathy.
    BIIE-0246 hydrochloride
  • HY-P1021
    Peptide YY (PYY) (3-36), porcine
    		Antagonist
    Peptide YY (PYY) (3-36), porcine is a gut hormone peptide that acts as a Y2 receptor agonist to reduce appetite.
    Peptide YY (PYY) (3-36), porcine
  • HY-148179
    Neuropeptide Y5 receptor ligand-1
    		Antagonist 98.0%
    Neuropeptide Y5 receptor ligand-1 (compound 54), a carbazole derivative, is a potent neuropeptide Y5 (NPY-5) receptor antagonist.
    Neuropeptide Y5 receptor ligand-1
  • HY-P4805
    Peptide YY (13-36) (canine, mouse, porcine, rat)
    		Agonist 99.22%
    Peptide YY (13-36) (canine, mouse, porcine, rat) is a Y2 receptor subtype agonist.
    Peptide YY (13-36) (canine, mouse, porcine, rat)
  • HY-P1438
    Neuropeptide S(Rat)
    		Agonist 99.57%
    Neuropeptide S (Rat) is an endogenous ligand of a previously orphan G-protein-coupled receptor now named NPS receptor. Neuropeptide S (Rat) can be used for the research of nervous system disease.
    Neuropeptide S(Rat)
  • HY-P3691
    CART (1-39), Human
    		99.79%
    CART (1-39), Human, Rat is a neuropeptide consisting of 1-39 residues of the CART peptide. CART (1-39), Human, Rat is a rat satiety factor with potent appetite-suppressing activity and is closely associated with leptin and neuropeptide Y. CART (1-39), Human, Rat inhibits both normal and starvation-induced feeding. CART (1-39), Human, Rat can induce anxiety and stress-related behavior.
    CART (1-39), Human
  • HY-P1578
    Galanin (1-16), mouse, porcine, rat
    		Agonist
    Galanin (1-16), mouse, porcine, rat is an agonist of the hippocampal galanin receptor, with a Kd of 3 nM.
    Galanin (1-16), mouse, porcine, rat
  • HY-P0262
    Galantide
    		Antagonist
    Galantide, a non-specific galanin receptor antagonist, is a peptide consisting of fragments of galanin and substance P. Galantide recognizes two classes of galanin binding sites (KD<0.1 nM and ~6 nM) in the rat hypothalamus. Galantide dose dependently (IC50=1.0 nM) antagonizes the galanin-mediated inhibition of the glucose-induced insulin secretion from mouse pancreatic islets. Galantide appears to bind to a single population of SP receptors (KD~40 nM).
    Galantide
  • HY-107382A
    RF9 hydrochloride
    		Antagonist 99.91%
    RF9 hydrochloride is a potent and selective Neuropeptide FF receptor antagonist, with Ki values of 58 and 75 nM for hNPFF1R and hNPFF2R, respectively.
    RF9 hydrochloride
Cat. No. Product Name / Synonyms Application Reactivity
Neuropeptide Y Receptor Isoform Comparison

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